Dr. Viper floods Megakat City with Katalyst X-63, an experimental formula that mutates any living thing it touches into grotesque, menacing versions of themselves.
The SWAT Kats of the title are two vigilante pilots who possess a state-of-the-art fighter jet with an array of weaponry. Throughout the series, they face various villains as well as competition from Megakat City's militarized police force called the Enforcers.
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