College friends Nick, Beth, Malik, Maya, Blake and Gordon are invited by their friend Sara Palski to spend the weekend at her saltwater lake house in Louisiana. They stop at a bar to buy supplies and Malik has some friction with the rednecks, Red and Dennis Crim, but Sara resolves the situation since Dennis is her ex-boyfriend. Then the group meets another friend of Sara, Sheriff Greg Sabin. When Malik is skiing in the lake, he has an accident resulting in having his arm severed by a shark and his friends trying to seek help. Instead, they learn that the lake is infested with several different species of sharks, and they have more dangerous problems threatening them.