ConAir (1997)

Just-paroled army ranger Cameron Poe is headed back to his wife, but must fly home aboard a prison transport flight dubbed "Jailbird" with some of the worst criminals living. Along with Diamond Dog and Baby-O, genius serial killer Cyrus "The Virus" Grissom unleashes a violent escape plot in mid-flight. Secretly working with U.S. Marshall Vince Larkin, Poe tries to foil Grissom's plan.