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Buy Norco Online What is Norco? Norco is an opioid-based medicine used to treat moderate to severe pain. It consists of an opioid pain reliever and a non-opioid pain reliever—named hydrocodone and acetaminophen respectively. Hydrocodone works in the brain to change how your body responds to pain, while acetaminophen helps in reducing fever. How to take Norco? Norco is taken orally and can be taken with or without food. In case of nausea, it may help to take this medicine with food. You can also ask your doctor about other ways to decrease nausea. If you are using the liquid form of this medicine, it is advised to use a medical measuring device instead of a household spoon, as that may lead to incorrect dosing.